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Structure of protein that forms fibrils in Parkinson's patients could lead

 The new findings explain how PINK1 is activated in cells, thereby cleaning up and replacing damaged mitochondria.


Australian researchers have solved a long-standing mystery surrounding Parkinson's disease. They have solved the structure of a key protein that is expected to cure this incurable disease. Discovery takes place in Nature.
Structure


For the first time, researchers have captured a protein called PINK1 "live" in Guest Posting. The discovery explains how this protein is activated in the cell, so it begins to clean and replace damaged mitochondria. When this protein doesn't work, it causes brain cells to lack energy, causing dysfunction that can lead to brain cell death in the long term.

The discovery is the latest breakthrough in an eight-year project that provides.

Parkinson's disease is a progressive neurodegenerative disease caused by death. More than 10 million people worldwide suffer from Parkinson's disease. There are no drugs that can slow or stop the progression of Parkinson's disease,

Zhong Gan Gan, the first author of the study, said that this study provides an unprecedented perspective to better understand. "Many papers in laboratories around the world, including ours, have taken pictures.


"What we did was to take pictures of a group of proteins and put them together to create a 'real world' movie, thereby revealing. We could then explain why these earlier structural pictures were different because they were." enabled to deliver."

PINK1 signaling damages mitochondria, allowing them to be destroyed and recycled. If PINK1 or other components of this pathway are defective or damaged.

"One of our key findings is that PINK1 forms a dimer, which is required to recruit or activate proteins to perform their functions. There are tens of thousands of papers on this family of proteins, but this is the first.


The corresponding author of the paper, Professor Panglima, said the findings pave. There is no cure for Parkinson's disease, meaning there are no treatments that can slow or stop the progression of the disease. "

Defects in PINK1 or other components of this pathway are considered key features in some cases of Parkinson's disease. At the same time, these data are very important for the young population, who develop Parkinson's disease due to inherited mutations in PINK1. Professor Commander said the discovery could lead to new treatments.

Dr. Alisa Gluhova, from the Walter and Eliza Hall Medical Research Institute, said the. met technology.

"For the first time at WEHI, we are using cryo-EM to solve the structure of a small protein-like PINK1. This revolutionary technology was only introduced in the last five years, and this work is possible because. to exploit this technology," said Dr. Glukhova. is a good example of how innovative technology can lead to transformative research and invention."
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