Skip to main content

Structure of protein that forms fibrils in Parkinson's patients could lead

 The new findings explain how PINK1 is activated in cells, thereby cleaning up and replacing damaged mitochondria.


Australian researchers have solved a long-standing mystery surrounding Parkinson's disease. They have solved the structure of a key protein that is expected to cure this incurable disease. Discovery takes place in Nature.
Structure


For the first time, researchers have captured a protein called PINK1 "live" in Guest Posting. The discovery explains how this protein is activated in the cell, so it begins to clean and replace damaged mitochondria. When this protein doesn't work, it causes brain cells to lack energy, causing dysfunction that can lead to brain cell death in the long term.

The discovery is the latest breakthrough in an eight-year project that provides.

Parkinson's disease is a progressive neurodegenerative disease caused by death. More than 10 million people worldwide suffer from Parkinson's disease. There are no drugs that can slow or stop the progression of Parkinson's disease,

Zhong Gan Gan, the first author of the study, said that this study provides an unprecedented perspective to better understand. "Many papers in laboratories around the world, including ours, have taken pictures.


"What we did was to take pictures of a group of proteins and put them together to create a 'real world' movie, thereby revealing. We could then explain why these earlier structural pictures were different because they were." enabled to deliver."

PINK1 signaling damages mitochondria, allowing them to be destroyed and recycled. If PINK1 or other components of this pathway are defective or damaged.

"One of our key findings is that PINK1 forms a dimer, which is required to recruit or activate proteins to perform their functions. There are tens of thousands of papers on this family of proteins, but this is the first.


The corresponding author of the paper, Professor Panglima, said the findings pave. There is no cure for Parkinson's disease, meaning there are no treatments that can slow or stop the progression of the disease. "

Defects in PINK1 or other components of this pathway are considered key features in some cases of Parkinson's disease. At the same time, these data are very important for the young population, who develop Parkinson's disease due to inherited mutations in PINK1. Professor Commander said the discovery could lead to new treatments.

Dr. Alisa Gluhova, from the Walter and Eliza Hall Medical Research Institute, said the. met technology.

"For the first time at WEHI, we are using cryo-EM to solve the structure of a small protein-like PINK1. This revolutionary technology was only introduced in the last five years, and this work is possible because. to exploit this technology," said Dr. Glukhova. is a good example of how innovative technology can lead to transformative research and invention."
Labels:

Comments

Post a Comment

Popular posts from this blog

Top best Services to look for in a Multi Speciality Hospital

  Learn about the facilities and specialties that make multi-specialty hospitals safe and secure. With the advancement of people and technology over time, Guest Accommodations! Earlier, most hospitals catered to specific specialties. But, today you can find many hospitals that offer multi-specialty treatment and diagnosis. Getting many treatments under one roof has become an easy entry point for many people. As with medical care, the procedures and systems used to deliver healthcare. Digital technology has enabled patient-centered services in many hospitals. It also helps leading hospitals improve their administrative and patient care processes. Global Hospital is the most specialized hospital in the country. It is the most popular center in India for various treatments and diagnoses. He is known for his clinical work in neuro, liver, and cardiology. From providing accurate diagnosis and surgical procedures to post-operative patient care services. Let's see how to get admission to...
Post a Comment
Read more

Top 75+ CSS Interview Questions You Should Prepare

  A trichologist is a specialist who deals with hair, scalp, and hair care. are experienced in diagnosing diseases that cause hair problems. Learn more about an in this article. A is a professional who deals with hair, scalp, and skin. The term "trichology" comes from the Greek word which means hair. prevent problems and improve your appearance. A trichologist is a specialist who deals with hair, scalp, and hair care. are experienced in diagnosing diseases that cause hair problems. Learn more about an in this article. A is a professional who deals with hair, scalp, and skin. The term "trichology" comes from the Greek word which means hair. prevent problems and improve your appearance. Here are some things you should know about the profession: Hair is made up of such as iron; and other macro- and micronutrients. The purpose of these vitamins is to keep our body healthy by preventing diseases such as anemia or iron deficiency Each phase lasts from t...
Post a Comment
Read more

12 Great Ways to Get Rid of Bloating

If you want to relieve gas and bloating, try these five yoga poses that are effective in reducing abdominal discomfort after eating as well as the pressure of gas trapped in your abdomen . If you want to relieve gas and bloating, try these five yoga poses that are effective in reducing abdominal discomfort after eating as well as the pressure of gas trapped in your abdomen . If you do any of these poses during pregnancy, check with your healthcare provider first to make sure they won't be dangerous to you or your baby . Forward Fold (Uttanasana) This position stretches your digestive tract. IBS can cause abdominal pain and cramping when you are gassy. The Forward Fold helps relieve these symptoms by elongating the spine and massaging the internal organs so they can move . It's also a good idea to take a few deep breaths in these poses before standing up again. The Butterfly Pose (Baddha Konasana) If you're prone to bloating, try sitting in the butterfly pose or with you...
Post a Comment
Read more